CHAPTER THREE
ACTIVATION FROM CATALEPSY IN MALE AND FEMALE RATS WITH NOVEL AND FAMILIAR KEY JINGLE OR CRUMPLING TIN FOIL VERSUS VESTIBULAR STIMULATION: A MODEL OF MUSIC-INDUCED IMPROVEMENT IN PARKINSON’S DISEASE
ABSTRACT
External cues including familiar music can release Parkinson’s disease patients from catalepsy but the neural basis of the effect is not well understood. The purpose of the present study was to develop an animal model of sound-induced behavioural activation that could be used to investigate the underlying neural mechanisms. The potency of novel versus familiar sound stimuli on release from haloperidol-induced (5 mg/kg) catalepsy was investigated in the rat in two experiments. Righting response to an auditory stimulus (single key jingle or multiple key jingles) was compared to angular change of an inclined grid in rats that were naïve or familiar with the stimuli. A movement rating system based on Eshkol-Wachman Movement Notation (EWMN) score was used to describe the size and speed of components of the righting response to cue presentation. Release from catalepsy was prompted by postural displacement and the auditory cue, familiar stimuli were more effective than unfamiliar stimuli, and the auditory cue produced a more normal temporal coupling of trunk and limb movements. Findings demonstrate we have developed a rat model of sound-induced behavioural activation that can be used to study the role of experience, sound, and neural mechanisms responsible for the therapeutic effect of music for Parkinson’s disease.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment